Drug interactions
Cefepime + Typhoid vaccine live
Severity: Moderate
Cefepime and Typhoid vaccine live: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Live oral typhoid vaccine (Ty21a) contains attenuated Salmonella Typhi that must colonize the gut to be effective. Antibacterial agents active against Salmonella may reduce vaccine viability and the immune response.
What this interaction means in plain words
Cefepime and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
The antibacterial activity can reduce replication of the live attenuated vaccine strain.
What to do
Give the live typhoid vaccine at least 24 hours after the last antibiotic dose (labeling for Ty21a suggests avoiding antibiotics around vaccination), or use the parenteral inactivated vaccine if antibiotics cannot be stopped.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefepime
- Amikacin + Cefepime Moderate
- Cefepime + Cholera vaccine Moderate
- Cefepime + Dexamethasone-tobramycin Moderate
- Cefepime + Gentamicin Moderate
- Cefepime + Kanamycin Moderate
- Cefepime + Microbiota Moderate
Frequently asked questions
Can I take Cefepime with Typhoid vaccine live?
MediHelp rates the interaction as moderate. Cefepime and Typhoid vaccine live can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Live oral typhoid vaccine (Ty21a) contains attenuated Salmonella Typhi that must colonize the gut to be effective. Antibacterial agents active against Salmonella may reduce vaccine viability and the immune response.
How serious is the interaction between Cefepime and Typhoid vaccine live?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give the live typhoid vaccine at least 24 hours after the last antibiotic dose (labeling for Ty21a suggests avoiding antibiotics around vaccination), or use the parenteral inactivated vaccine if antibiotics cannot be stopped.
What other medicines interact with Cefepime?
MediHelp also lists interactions of Cefepime with, for example, Amikacin, Cholera vaccine, Dexamethasone-tobramycin. The full list is on the Cefepime page.
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