Drug interactions
Cefepime / enmetazobactam + Probenecid
Severity: Moderate
Cefepime / enmetazobactam and Probenecid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Probenecid may reduce the renal secretion of cefepime and enmetazobactam, increasing their exposure. Enmetazobactam labeling advises against coadministration with probenecid because its renal elimination depends on active secretion.
What this interaction means in plain words
Cefepime / enmetazobactam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Probenecid inhibits renal organic anion transporters that secrete enmetazobactam and cefepime.
What to do
Avoid concomitant use where possible; if needed, monitor for beta-lactam adverse effects such as neurotoxicity, particularly in renal impairment.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Probenecid
- Ketorolac intranasal + Probenecid Contraindicated
- Ketorolac + Probenecid Contraindicated
- Baricitinib + Probenecid Major
- Ceftazidime / avibactam + Probenecid Major
- Methotrexate + Probenecid Major
- Pralatrexate + Probenecid Major
Frequently asked questions
Can I take Cefepime / enmetazobactam with Probenecid?
MediHelp rates the interaction as moderate. Cefepime / enmetazobactam and Probenecid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Probenecid may reduce the renal secretion of cefepime and enmetazobactam, increasing their exposure. Enmetazobactam labeling advises against coadministration with probenecid because its renal elimination depends on active secretion.
How serious is the interaction between Cefepime / enmetazobactam and Probenecid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concomitant use where possible; if needed, monitor for beta-lactam adverse effects such as neurotoxicity, particularly in renal impairment.
What other medicines interact with Probenecid?
MediHelp also lists interactions of Probenecid with, for example, Ketorolac intranasal, Ketorolac, Baricitinib. The full list is on the Probenecid page.
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