Drug interactions
Cefiderocol + Warfarin
Severity: Moderate
Cefiderocol and Warfarin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Antibiotic therapy with cefiderocol may raise INR in patients on warfarin, particularly in acutely ill patients. Direct evidence is limited.
What this interaction means in plain words
Cefiderocol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefiderocol belongs to Anti Bacterial; Warfarin belongs to Cardiovascular.
Why it happens
Possible reduction of vitamin K-producing gut flora; the mechanism is not firmly established.
What to do
Check INR within several days of starting cefiderocol and adjust warfarin dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Warfarin
- Defibrotide + Warfarin Contraindicated
- Ketorolac + Warfarin Contraindicated
- Abciximab + Warfarin Major
- Acetylsalicylic acid + Warfarin Major
- Adagrasib + Warfarin Major
- Amiodarone + Warfarin Major
Other interactions of Cefiderocol
- Amikacin + Cefiderocol Moderate
- Cefiderocol + Streptomycin Moderate
- Cefiderocol + Dexamethasone-tobramycin Minor
- Cefiderocol + Gentamicin Minor
Frequently asked questions
Can I take Cefiderocol with Warfarin?
MediHelp rates the interaction as moderate. Cefiderocol and Warfarin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Antibiotic therapy with cefiderocol may raise INR in patients on warfarin, particularly in acutely ill patients. Direct evidence is limited.
How serious is the interaction between Cefiderocol and Warfarin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Check INR within several days of starting cefiderocol and adjust warfarin dose as needed.
What other medicines interact with Warfarin?
MediHelp also lists interactions of Warfarin with, for example, Defibrotide, Ketorolac, Abciximab. The full list is on the Warfarin page.
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