Drug interactions
Cefixime + Cyclopenthiazide
Severity: Minor
Cefixime and Cyclopenthiazide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Both drugs are secreted by renal organic anion transporters in the proximal tubule, so competition is theoretically possible. No meaningful clinical consequence has been established.
What this interaction means in plain words
Cefixime and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Competition for renal tubular organic anion secretion.
What to do
No routine adjustment is needed; monitor renal function and electrolytes as usual during diuretic therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefixime with Cyclopenthiazide?
MediHelp rates the interaction as minor. Cefixime and Cyclopenthiazide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Both drugs are secreted by renal organic anion transporters in the proximal tubule, so competition is theoretically possible. No meaningful clinical consequence has been established.
How serious is the interaction between Cefixime and Cyclopenthiazide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment is needed; monitor renal function and electrolytes as usual during diuretic therapy.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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