Drug interactions
Cefixime + Dexamethasone-tobramycin
Severity: Minor
Cefixime and Dexamethasone-tobramycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent cephalosporin and aminoglycoside therapy has been associated with additive kidney injury, mainly in at-risk patients. Cefixime is an oral agent with little nephrotoxic potential, so the risk is small.
What this interaction means in plain words
Cefixime and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefixime belongs to Anti Bacterial; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity; mechanism not firmly established for this cephalosporin.
What to do
Monitor renal function and tobramycin levels as usual during aminoglycoside therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefixime and Dexamethasone-tobramycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Dexamethasone-tobramycin
Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefixime with Dexamethasone-tobramycin?
MediHelp rates the interaction as minor. Cefixime and Dexamethasone-tobramycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Concurrent cephalosporin and aminoglycoside therapy has been associated with additive kidney injury, mainly in at-risk patients. Cefixime is an oral agent with little nephrotoxic potential, so the risk is small.
How serious is the interaction between Cefixime and Dexamethasone-tobramycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and tobramycin levels as usual during aminoglycoside therapy.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
