Drug interactions
Cefixime + Neomycin po
Severity: Minor
Cefixime and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed, so systemic nephrotoxicity and ototoxicity are uncommon, though absorption can increase with inflamed or damaged bowel or renal impairment. Combined with cefixime, a clinically relevant additive effect is unlikely in most patients.
What this interaction means in plain words
Cefixime and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive nephrotoxicity if neomycin is absorbed systemically.
What to do
No routine action is needed. Monitor renal function if the patient has renal impairment, bowel inflammation or prolonged neomycin use.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefixime
- Cefixime + Typhoid vaccine live Major
- Cefixime + Cholera vaccine Moderate
- Cefixime + Kanamycin Moderate
- Cefixime + Microbiota Moderate
- Cefixime + Plazomicin Moderate
- Cefixime + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Frequently asked questions
Can I take Cefixime with Neomycin po?
MediHelp rates the interaction as minor. Cefixime and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed, so systemic nephrotoxicity and ototoxicity are uncommon, though absorption can increase with inflamed or damaged bowel or renal impairment. Combined with cefixime, a clinically relevant additive effect is unlikely in most patients.
How serious is the interaction between Cefixime and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed. Monitor renal function if the patient has renal impairment, bowel inflammation or prolonged neomycin use.
What other medicines interact with Cefixime?
MediHelp also lists interactions of Cefixime with, for example, Typhoid vaccine live, Cholera vaccine, Kanamycin. The full list is on the Cefixime page.
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