Drug interactions
Cefotaxime + Streptomycin
Severity: Moderate
Cefotaxime and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and aminoglycosides carry their own risk of hearing and vestibular damage. The additive risk with cefotaxime is modest and mainly reported in patients with other risk factors such as renal impairment, advanced age or dehydration.
What this interaction means in plain words
Cefotaxime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefotaxime belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Possible additive nephrotoxicity, with aminoglycoside-related renal tubular injury potentially worsening renal clearance and thus ototoxic exposure.
What to do
Monitor serum creatinine and urine output regularly and keep the patient well hydrated. Monitor streptomycin levels where available and assess hearing and vestibular function during prolonged courses.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefotaxime
- Cefotaxime + Typhoid vaccine live Major
- Amikacin + Cefotaxime Moderate
- Cefotaxime + Cholera vaccine Moderate
- Cefotaxime + Dexamethasone-tobramycin Moderate
- Cefotaxime + Gentamicin Moderate
- Cefotaxime + Kanamycin Moderate
Other interactions of Streptomycin
Frequently asked questions
Can I take Cefotaxime with Streptomycin?
MediHelp rates the interaction as moderate. Cefotaxime and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining a cephalosporin with an aminoglycoside may raise the risk of kidney injury, and aminoglycosides carry their own risk of hearing and vestibular damage. The additive risk with cefotaxime is modest and mainly reported in patients with other risk factors such as renal impairment, advanced age or dehydration.
How serious is the interaction between Cefotaxime and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and urine output regularly and keep the patient well hydrated. Monitor streptomycin levels where available and assess hearing and vestibular function during prolonged courses.
What other medicines interact with Cefotaxime?
MediHelp also lists interactions of Cefotaxime with, for example, Typhoid vaccine live, Amikacin, Cholera vaccine. The full list is on the Cefotaxime page.
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