Drug interactions
Cefoxitin + Heparin
Severity: Minor
Cefoxitin and Heparin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cefoxitin does not meaningfully alter the anticoagulant effect of heparin. Perioperative co-use is routine. Any added bleeding risk is theoretical.
What this interaction means in plain words
Cefoxitin and Heparin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Cefoxitin belongs to Anti Bacterial; Heparin belongs to Cardiovascular.
Why it happens
No established mechanism; cefoxitin has negligible effect on clotting factor synthesis.
What to do
Monitor aPTT or anti-Xa per heparin protocol; no cefoxitin-specific adjustment is needed.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefoxitin
- Amikacin + Cefoxitin Moderate
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Dexamethasone-tobramycin Moderate
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Cefoxitin with Heparin?
MediHelp rates the interaction as minor. Cefoxitin and Heparin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cefoxitin does not meaningfully alter the anticoagulant effect of heparin. Perioperative co-use is routine. Any added bleeding risk is theoretical.
How serious is the interaction between Cefoxitin and Heparin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor aPTT or anti-Xa per heparin protocol; no cefoxitin-specific adjustment is needed.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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