Drug interactions
Cefoxitin + Neomycin po
Severity: Minor
Cefoxitin and Neomycin po: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Oral neomycin is poorly absorbed in healthy gut, so systemic exposure is usually small. Absorption can rise with damaged bowel mucosa or renal impairment, and in that case any additive nephrotoxicity with a cephalosporin becomes relevant.
What this interaction means in plain words
Cefoxitin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive nephrotoxicity if neomycin is absorbed systemically.
What to do
No routine action is needed with intact bowel and normal renal function. In renal impairment or inflamed bowel, monitor serum creatinine.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefoxitin
- Amikacin + Cefoxitin Moderate
- Aztreonam + Cefoxitin Moderate
- Bcg vaccine live + Cefoxitin Moderate
- Cefoxitin + Chloramphenicol Moderate
- Cefoxitin + Cholera vaccine Moderate
- Cefoxitin + Dexamethasone-tobramycin Moderate
Frequently asked questions
Can I take Cefoxitin with Neomycin po?
MediHelp rates the interaction as minor. Cefoxitin and Neomycin po have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Oral neomycin is poorly absorbed in healthy gut, so systemic exposure is usually small. Absorption can rise with damaged bowel mucosa or renal impairment, and in that case any additive nephrotoxicity with a cephalosporin becomes relevant.
How serious is the interaction between Cefoxitin and Neomycin po?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine action is needed with intact bowel and normal renal function. In renal impairment or inflamed bowel, monitor serum creatinine.
What other medicines interact with Cefoxitin?
MediHelp also lists interactions of Cefoxitin with, for example, Amikacin, Aztreonam, Bcg vaccine live. The full list is on the Cefoxitin page.
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