Drug interactions
Cefprozil + Kanamycin
Severity: Minor
Cefprozil and Kanamycin: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Kanamycin is nephrotoxic and ototoxic, and cephalosporins have occasionally been linked to additional renal injury when given with aminoglycosides. Oral cefprozil with parenteral kanamycin carries limited added risk, but renal decline would raise aminoglycoside levels and toxicity.
What this interaction means in plain words
Cefprozil and Kanamycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Possible additive nephrotoxicity with reduced renal clearance of the aminoglycoside.
What to do
Monitor serum creatinine during kanamycin therapy and adjust the kanamycin dose to renal function and drug levels.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Cefprozil and Kanamycin, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Cefprozil with Kanamycin?
MediHelp rates the interaction as minor. Cefprozil and Kanamycin have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Kanamycin is nephrotoxic and ototoxic, and cephalosporins have occasionally been linked to additional renal injury when given with aminoglycosides. Oral cefprozil with parenteral kanamycin carries limited added risk, but renal decline would raise aminoglycoside levels and toxicity.
How serious is the interaction between Cefprozil and Kanamycin?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine during kanamycin therapy and adjust the kanamycin dose to renal function and drug levels.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
