Drug interactions
Cefprozil + Gentamicin
Severity: Moderate
Cefprozil and Gentamicin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Gentamicin carries a risk of kidney injury and ototoxicity, and cephalosporins may contribute to renal toxicity in some reports. Impaired kidney function raises gentamicin concentrations, which increases the risk of permanent inner ear damage.
What this interaction means in plain words
Cefprozil and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefprozil belongs to Anti Bacterial; Gentamicin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxicity, with reduced clearance increasing aminoglycoside exposure.
What to do
Monitor serum creatinine and gentamicin trough levels, and assess hearing and balance. Adjust the gentamicin dose to renal function and limit duration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
- Cefprozil + Sodium picosulfate / magnesium oxide / anhydrous citric acid Moderate
Other interactions of Gentamicin
- Cidofovir + Gentamicin Contraindicated
- Adefovir + Gentamicin Major
- Amikacin + Gentamicin Major
- Amlodipine-hydrochlorothiazide-valsartan + Gentamicin Major
- Amphotericin b deoxycholate + Gentamicin Major
- Amphotericin b + Gentamicin Major
Frequently asked questions
Can I take Cefprozil with Gentamicin?
MediHelp rates the interaction as moderate. Cefprozil and Gentamicin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Gentamicin carries a risk of kidney injury and ototoxicity, and cephalosporins may contribute to renal toxicity in some reports. Impaired kidney function raises gentamicin concentrations, which increases the risk of permanent inner ear damage.
How serious is the interaction between Cefprozil and Gentamicin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum creatinine and gentamicin trough levels, and assess hearing and balance. Adjust the gentamicin dose to renal function and limit duration.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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