Drug interactions
Cefprozil + Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate
Severity: Minor
Cefprozil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Non-rifamycin antibiotics such as cefprozil have been theorised to reduce the effectiveness of combined oral contraceptives by disturbing gut bacteria that recycle ethinylestradiol. Pharmacokinetic studies have generally not shown meaningful drops in hormone levels, and the real-world risk of contraceptive failure is considered low.
What this interaction means in plain words
Cefprozil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recirculation of ethinylestradiol through altered intestinal flora.
What to do
No routine change is needed; counsel the patient to take the contraceptive consistently. Advise backup contraception if vomiting or severe diarrhoea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Cefprozil with Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates the interaction as minor. Cefprozil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Non-rifamycin antibiotics such as cefprozil have been theorised to reduce the effectiveness of combined oral contraceptives by disturbing gut bacteria that recycle ethinylestradiol. Pharmacokinetic studies have generally not shown meaningful drops in hormone levels, and the real-world risk of contraceptive failure is considered low.
How serious is the interaction between Cefprozil and Levonorgestrel oral / ethinylestradiol / ferrous bisglycinate?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; counsel the patient to take the contraceptive consistently. Advise backup contraception if vomiting or severe diarrhoea occurs.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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