Drug interactions
Cefprozil + Mestranol
Severity: Minor
Cefprozil and Mestranol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Broad-spectrum antibiotics have been theorised to lower oral estrogen exposure by reducing gut bacterial hydrolysis of conjugated estrogens, which could in principle reduce contraceptive reliability. Clinical data do not show consistent loss of efficacy with cephalosporins.
What this interaction means in plain words
Cefprozil and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical reduction of enterohepatic recirculation of estrogen due to altered intestinal flora.
What to do
No routine change is needed; reinforce adherence to the contraceptive. Recommend backup contraception if vomiting or severe diarrhoea occurs.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Cefprozil with Mestranol?
MediHelp rates the interaction as minor. Cefprozil and Mestranol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Broad-spectrum antibiotics have been theorised to lower oral estrogen exposure by reducing gut bacterial hydrolysis of conjugated estrogens, which could in principle reduce contraceptive reliability. Clinical data do not show consistent loss of efficacy with cephalosporins.
How serious is the interaction between Cefprozil and Mestranol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine change is needed; reinforce adherence to the contraceptive. Recommend backup contraception if vomiting or severe diarrhoea occurs.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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