Drug interactions
Cefprozil + Sodium picosulfate / magnesium oxide / anhydrous citric acid
Severity: Moderate
Cefprozil and Sodium picosulfate / magnesium oxide / anhydrous citric acid: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Sodium picosulfate is a prodrug that colonic bacteria convert to its active laxative form. Antibiotics that suppress colonic flora may reduce this conversion and result in poorer bowel cleansing before colonoscopy.
What this interaction means in plain words
Cefprozil and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Antibiotic-induced suppression of colonic bacteria needed to activate sodium picosulfate.
What to do
Avoid giving the antibiotic before or during bowel preparation where possible. If it is essential, assess the quality of bowel cleansing and consider an alternative preparation.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefprozil
- Amikacin + Cefprozil Moderate
- Bcg vaccine live + Cefprozil Moderate
- Cefprozil + Cholera vaccine Moderate
- Cefprozil + Gentamicin Moderate
- Cefprozil + Microbiota Moderate
- Cefprozil + Plazomicin Moderate
Frequently asked questions
Can I take Cefprozil with Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates the interaction as moderate. Cefprozil and Sodium picosulfate / magnesium oxide / anhydrous citric acid can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Sodium picosulfate is a prodrug that colonic bacteria convert to its active laxative form. Antibiotics that suppress colonic flora may reduce this conversion and result in poorer bowel cleansing before colonoscopy.
How serious is the interaction between Cefprozil and Sodium picosulfate / magnesium oxide / anhydrous citric acid?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid giving the antibiotic before or during bowel preparation where possible. If it is essential, assess the quality of bowel cleansing and consider an alternative preparation.
What other medicines interact with Cefprozil?
MediHelp also lists interactions of Cefprozil with, for example, Amikacin, Bcg vaccine live, Cholera vaccine. The full list is on the Cefprozil page.
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