Drug interactions
Ceftobiprole medocaril + Rosuvastatin
Severity: Moderate
Ceftobiprole medocaril and Rosuvastatin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Ceftobiprole inhibits hepatic uptake transporters and may raise rosuvastatin levels. This could increase the risk of muscle toxicity.
What this interaction means in plain words
Ceftobiprole medocaril and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Inhibition of OATP1B1/1B3 reduces hepatic uptake of rosuvastatin.
What to do
Monitor for muscle symptoms during the short antibiotic course. Consider temporarily holding rosuvastatin if the antibiotic course is prolonged or symptoms appear.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Ceftobiprole medocaril with Rosuvastatin?
MediHelp rates the interaction as moderate. Ceftobiprole medocaril and Rosuvastatin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Ceftobiprole inhibits hepatic uptake transporters and may raise rosuvastatin levels. This could increase the risk of muscle toxicity.
How serious is the interaction between Ceftobiprole medocaril and Rosuvastatin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for muscle symptoms during the short antibiotic course. Consider temporarily holding rosuvastatin if the antibiotic course is prolonged or symptoms appear.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporin, Darolutamide. The full list is on the Rosuvastatin page.
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