Drug interactions
Darolutamide + Rosuvastatin
Severity: Major
Darolutamide and Rosuvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Darolutamide inhibits BCRP and increases rosuvastatin exposure. Higher levels raise the risk of muscle toxicity.
What this interaction means in plain words
Darolutamide and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Darolutamide belongs to Miscellaneous; Rosuvastatin belongs to Cardiovascular.
Why it happens
Darolutamide inhibits BCRP-mediated intestinal efflux of rosuvastatin.
What to do
Avoid if possible; otherwise limit rosuvastatin to 5 mg daily and monitor for muscle symptoms.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rosuvastatin
Other interactions of Darolutamide
Frequently asked questions
Can I take Darolutamide with Rosuvastatin?
MediHelp rates the interaction as major. Darolutamide and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Darolutamide inhibits BCRP and increases rosuvastatin exposure. Higher levels raise the risk of muscle toxicity.
How serious is the interaction between Darolutamide and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid if possible; otherwise limit rosuvastatin to 5 mg daily and monitor for muscle symptoms.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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