Drug interactions
Dasabuvir + Rosuvastatin
Severity: Major
Dasabuvir and Rosuvastatin: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dasabuvir, within the ombitasvir/paritaprevir/ritonavir regimen, inhibits transporters involved in rosuvastatin handling and raises its exposure. This increases the risk of myopathy and rhabdomyolysis.
What this interaction means in plain words
Dasabuvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Inhibition of OATP1B1 and BCRP transporters (BCRP inhibition by dasabuvir) increases rosuvastatin plasma concentrations.
What to do
Limit rosuvastatin to the lowest dose consistent with labeling for the regimen and monitor for muscle symptoms; consider an alternative statin or temporary suspension.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Rosuvastatin
Frequently asked questions
Can I take Dasabuvir with Rosuvastatin?
MediHelp rates the interaction as major. Dasabuvir and Rosuvastatin can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Dasabuvir, within the ombitasvir/paritaprevir/ritonavir regimen, inhibits transporters involved in rosuvastatin handling and raises its exposure. This increases the risk of myopathy and rhabdomyolysis.
How serious is the interaction between Dasabuvir and Rosuvastatin?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Limit rosuvastatin to the lowest dose consistent with labeling for the regimen and monitor for muscle symptoms; consider an alternative statin or temporary suspension.
What other medicines interact with Rosuvastatin?
MediHelp also lists interactions of Rosuvastatin with, for example, Atazanavir, Cyclosporine, Cyclosporin. The full list is on the Rosuvastatin page.
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