Drug interactions
Ceftriaxone + Streptomycin
Severity: Moderate
Ceftriaxone and Streptomycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity and vestibular toxicity may also be a concern.
What this interaction means in plain words
Ceftriaxone and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Ceftriaxone belongs to Anti Bacterial; Streptomycin belongs to Anti Bacterial.
Why it happens
Additive nephrotoxic potential, with aminoglycoside tubular toxicity possibly being aggravated by cephalosporins.
What to do
Monitor renal function and auditory/vestibular symptoms during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Ceftriaxone
- Calcium chloride + Ceftriaxone Contraindicated
- Calcium gluconate + Ceftriaxone Contraindicated
- Calcium + Ceftriaxone Contraindicated
- Ceftriaxone + Lactated ringer's Contraindicated
- Ceftriaxone + Ringer's solution Contraindicated
- Calcium acetate + Ceftriaxone Major
Other interactions of Streptomycin
Frequently asked questions
Can I take Ceftriaxone with Streptomycin?
MediHelp rates the interaction as moderate. Ceftriaxone and Streptomycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use of a cephalosporin with an aminoglycoside has been associated with additive kidney injury in some reports, particularly in patients with other risk factors. Aminoglycoside ototoxicity and vestibular toxicity may also be a concern.
How serious is the interaction between Ceftriaxone and Streptomycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and auditory/vestibular symptoms during combined therapy, and keep the aminoglycoside course as short as possible. Maintain hydration and avoid other nephrotoxins.
What other medicines interact with Ceftriaxone?
MediHelp also lists interactions of Ceftriaxone with, for example, Calcium chloride, Calcium gluconate, Calcium. The full list is on the Ceftriaxone page.
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