Drug interactions
Cefuroxime + Didanosine
Severity: Moderate
Cefuroxime and Didanosine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Didanosine chewable or buffered formulations contain antacid buffers that raise gastric pH, which can lower the absorption of cefuroxime axetil. This may reduce antibiotic exposure and lead to treatment failure.
What this interaction means in plain words
Cefuroxime and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Cefuroxime belongs to Anti Bacterial; Didanosine belongs to Anti Virals.
Why it happens
Higher gastric pH from the buffer reduces dissolution and absorption of oral cefuroxime axetil.
What to do
Give cefuroxime axetil about 2 hours before the buffered didanosine formulation, or use an unbuffered didanosine formulation. Watch the clinical response to the antibiotic.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Cefuroxime
- Aluminum hydroxide + Cefuroxime Moderate
- Amikacin + Cefuroxime Moderate
- Bcg vaccine live + Cefuroxime Moderate
- Calcium carbonate + Cefuroxime Moderate
- Calcium + Cefuroxime Moderate
- Cefuroxime + Cholera vaccine Moderate
Other interactions of Didanosine
- Didanosine + Elvitegravir / cobicistat / emtricitabine / tenofovir df Contraindicated
- Didanosine + Hydroxycarbamide Contraindicated
- Didanosine + Ribavirin Contraindicated
- Didanosine + Stavudine Contraindicated
- Allopurinol + Didanosine Major
- Atidarsagene autotemcel + Didanosine Major
Frequently asked questions
Can I take Cefuroxime with Didanosine?
MediHelp rates the interaction as moderate. Cefuroxime and Didanosine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Didanosine chewable or buffered formulations contain antacid buffers that raise gastric pH, which can lower the absorption of cefuroxime axetil. This may reduce antibiotic exposure and lead to treatment failure.
How serious is the interaction between Cefuroxime and Didanosine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Give cefuroxime axetil about 2 hours before the buffered didanosine formulation, or use an unbuffered didanosine formulation. Watch the clinical response to the antibiotic.
What other medicines interact with Cefuroxime?
MediHelp also lists interactions of Cefuroxime with, for example, Aluminum hydroxide, Amikacin, Bcg vaccine live. The full list is on the Cefuroxime page.
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