Drug interactions
Celecoxib + Choline magnesium trisalicylate
Severity: Moderate
Celecoxib and Choline magnesium trisalicylate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining celecoxib with a salicylate increases the risk of gastrointestinal bleeding and renal toxicity without added benefit. Salicylates also have antiplatelet activity that adds to bleeding risk.
What this interaction means in plain words
Celecoxib and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive cyclooxygenase inhibition causing mucosal injury, platelet dysfunction and renal prostaglandin suppression.
What to do
Avoid using both together and choose a single agent at the lowest effective dose. If combined, monitor for GI bleeding and renal function and consider gastroprotection.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Choline magnesium trisalicylate?
MediHelp rates the interaction as moderate. Celecoxib and Choline magnesium trisalicylate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Combining celecoxib with a salicylate increases the risk of gastrointestinal bleeding and renal toxicity without added benefit. Salicylates also have antiplatelet activity that adds to bleeding risk.
How serious is the interaction between Celecoxib and Choline magnesium trisalicylate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid using both together and choose a single agent at the lowest effective dose. If combined, monitor for GI bleeding and renal function and consider gastroprotection.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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