Drug interactions
Celecoxib + Cinnamon
Severity: Minor
Celecoxib and Cinnamon: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Cinnamon, particularly cassia types rich in coumarin, may have mild antiplatelet or anticoagulant activity. Combined with celecoxib, which impairs gastric mucosal protection, this could slightly raise bleeding risk. Clinical evidence is limited.
What this interaction means in plain words
Celecoxib and Cinnamon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive effects on hemostasis from coumarin content or platelet inhibition, combined with NSAID-related GI mucosal injury.
What to do
Ask patients about supplement use and advise against high-dose cinnamon supplements during celecoxib therapy. Monitor for GI bleeding or bruising if used regularly.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Cinnamon?
MediHelp rates the interaction as minor. Celecoxib and Cinnamon have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Cinnamon, particularly cassia types rich in coumarin, may have mild antiplatelet or anticoagulant activity. Combined with celecoxib, which impairs gastric mucosal protection, this could slightly raise bleeding risk. Clinical evidence is limited.
How serious is the interaction between Celecoxib and Cinnamon?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Ask patients about supplement use and advise against high-dose cinnamon supplements during celecoxib therapy. Monitor for GI bleeding or bruising if used regularly.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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