Drug interactions
Celecoxib + Citalopram
Severity: Moderate
Celecoxib and Citalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Citalopram impairs platelet function and, with an NSAID, raises the risk of bleeding, particularly upper gastrointestinal bleeding. Celecoxib has less GI toxicity than non-selective NSAIDs, but the added risk remains.
What this interaction means in plain words
Celecoxib and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Citalopram belongs to Central Nervous System.
Why it happens
SSRI-induced platelet serotonin depletion impairs aggregation, additive to NSAID effects on the gastric mucosa and hemostasis.
What to do
Monitor for GI bleeding and consider a proton pump inhibitor in older or high-risk patients. Use the lowest effective celecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Citalopram
- Cisapride + Citalopram Contraindicated
- Citalopram + Dronedarone Contraindicated
- Citalopram + Escitalopram Contraindicated
- Citalopram + Isocarboxazid Contraindicated
- Citalopram + Methylene blue Contraindicated
- Citalopram + Phenelzine Contraindicated
Frequently asked questions
Can I take Celecoxib with Citalopram?
MediHelp rates the interaction as moderate. Celecoxib and Citalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Citalopram impairs platelet function and, with an NSAID, raises the risk of bleeding, particularly upper gastrointestinal bleeding. Celecoxib has less GI toxicity than non-selective NSAIDs, but the added risk remains.
How serious is the interaction between Celecoxib and Citalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for GI bleeding and consider a proton pump inhibitor in older or high-risk patients. Use the lowest effective celecoxib dose for the shortest time.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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