Drug interactions
Celecoxib + Cortisone
Severity: Moderate
Celecoxib and Cortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent NSAIDs and systemic corticosteroids increase the risk of peptic ulceration and gastrointestinal bleeding more than either alone. Celecoxib has lower GI risk than non-selective NSAIDs, but the risk is still raised with steroids. Fluid retention may also be additive.
What this interaction means in plain words
Celecoxib and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive impairment of gastric mucosal defense through prostaglandin inhibition (NSAID) and corticosteroid effects on mucosal healing.
What to do
Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection in at-risk patients. Monitor for GI bleeding symptoms, and for blood pressure and fluid retention.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Cortisone?
MediHelp rates the interaction as moderate. Celecoxib and Cortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent NSAIDs and systemic corticosteroids increase the risk of peptic ulceration and gastrointestinal bleeding more than either alone. Celecoxib has lower GI risk than non-selective NSAIDs, but the risk is still raised with steroids. Fluid retention may also be additive.
How serious is the interaction between Celecoxib and Cortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest duration and consider a proton pump inhibitor for gastroprotection in at-risk patients. Monitor for GI bleeding symptoms, and for blood pressure and fluid retention.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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