Drug interactions
Celecoxib + Cyclopenthiazide
Severity: Moderate
Celecoxib and Cyclopenthiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effect of thiazides through sodium and water retention. Combined use also raises the risk of renal impairment, especially with volume depletion. Potassium effects are opposing and of minor importance.
What this interaction means in plain words
Celecoxib and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandin synthesis reduces renal blood flow and natriuresis, antagonizing thiazide action.
What to do
Monitor blood pressure, renal function and electrolytes, especially at initiation and in elderly or dehydrated patients. Ensure adequate hydration and adjust the diuretic dose if needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Cyclopenthiazide?
MediHelp rates the interaction as moderate. Celecoxib and Cyclopenthiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effect of thiazides through sodium and water retention. Combined use also raises the risk of renal impairment, especially with volume depletion. Potassium effects are opposing and of minor importance.
How serious is the interaction between Celecoxib and Cyclopenthiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, especially at initiation and in elderly or dehydrated patients. Ensure adequate hydration and adjust the diuretic dose if needed.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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