Drug interactions
Celecoxib + Dabigatran
Severity: Major
Celecoxib and Dabigatran: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs added to dabigatran increase the risk of clinically significant bleeding, including gastrointestinal bleeding. Celecoxib has minimal platelet effect but still causes mucosal injury and may reduce renal function, which raises dabigatran exposure.
What this interaction means in plain words
Celecoxib and Dabigatran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive bleeding risk from anticoagulation plus NSAID-related GI mucosal injury; possible reduced renal clearance of dabigatran.
What to do
Avoid the combination where possible and use paracetamol for analgesia. If needed, use the shortest course, consider gastroprotection, and monitor renal function and for bleeding.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Dabigatran?
MediHelp rates the interaction as major. Celecoxib and Dabigatran can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. NSAIDs added to dabigatran increase the risk of clinically significant bleeding, including gastrointestinal bleeding. Celecoxib has minimal platelet effect but still causes mucosal injury and may reduce renal function, which raises dabigatran exposure.
How serious is the interaction between Celecoxib and Dabigatran?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid the combination where possible and use paracetamol for analgesia. If needed, use the shortest course, consider gastroprotection, and monitor renal function and for bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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