Drug interactions
Celecoxib + Danshen
Severity: Moderate
Celecoxib and Danshen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant-like activity and has been associated with increased bleeding, mostly with warfarin. Combining it with celecoxib may add to bleeding risk.
What this interaction means in plain words
Celecoxib and Danshen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects, with COX inhibition from celecoxib and platelet inhibition from danshen.
What to do
Advise patients to avoid danshen while on an NSAID, especially if they also take anticoagulants. Monitor for bleeding.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Danshen?
MediHelp rates the interaction as moderate. Celecoxib and Danshen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Danshen (Salvia miltiorrhiza) has antiplatelet and anticoagulant-like activity and has been associated with increased bleeding, mostly with warfarin. Combining it with celecoxib may add to bleeding risk.
How serious is the interaction between Celecoxib and Danshen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise patients to avoid danshen while on an NSAID, especially if they also take anticoagulants. Monitor for bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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