Drug interactions
Celecoxib + Dexamethasone-tobramycin
Severity: Moderate
Celecoxib and Dexamethasone-tobramycin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids and NSAIDs together raise the risk of gastrointestinal ulceration and bleeding. Celecoxib carries a lower GI risk than non-selective NSAIDs but the risk is still raised. Systemic exposure from topical or ophthalmic dexamethasone-tobramycin is low, so the effect is mostly relevant to systemic corticosteroid use.
What this interaction means in plain words
Celecoxib and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Dexamethasone-tobramycin belongs to Anti Bacterial.
Why it happens
Additive mucosal injury, as corticosteroids impair mucosal healing while NSAIDs reduce protective prostaglandins.
What to do
Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for GI bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Dexamethasone-tobramycin
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Dexamethasone-tobramycin?
MediHelp rates the interaction as moderate. Celecoxib and Dexamethasone-tobramycin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids and NSAIDs together raise the risk of gastrointestinal ulceration and bleeding. Celecoxib carries a lower GI risk than non-selective NSAIDs but the risk is still raised. Systemic exposure from topical or ophthalmic dexamethasone-tobramycin is low, so the effect is mostly relevant to systemic corticosteroid use.
How serious is the interaction between Celecoxib and Dexamethasone-tobramycin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider gastroprotection with a proton pump inhibitor in high-risk patients. Monitor for GI bleeding symptoms.
What other medicines interact with Dexamethasone-tobramycin?
MediHelp also lists interactions of Dexamethasone-tobramycin with, for example, Capreomycin, Carboplatin, Ciprofloxacin. The full list is on the Dexamethasone-tobramycin page.
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