Drug interactions
Celecoxib + Dextroamphetamine
Severity: Minor
Celecoxib and Dextroamphetamine: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib could slightly increase dextroamphetamine exposure by weak CYP2D6 inhibition. Dextroamphetamine is also eliminated unchanged in urine, so the effect is likely small.
What this interaction means in plain words
Celecoxib and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Dextroamphetamine belongs to Central Nervous System.
Why it happens
Celecoxib weakly inhibits CYP2D6, a minor pathway for amphetamine metabolism.
What to do
No dose change is generally needed; monitor heart rate, blood pressure and stimulant adverse effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Dextroamphetamine
- Dextroamphetamine + Isocarboxazid Contraindicated
- Dextroamphetamine + Linezolid Contraindicated
- Dextroamphetamine + Methylene blue Contraindicated
- Dextroamphetamine + Phenelzine Contraindicated
- Dextroamphetamine + Rasagiline Contraindicated
- Dextroamphetamine + Safinamide Contraindicated
Frequently asked questions
Can I take Celecoxib with Dextroamphetamine?
MediHelp rates the interaction as minor. Celecoxib and Dextroamphetamine have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib could slightly increase dextroamphetamine exposure by weak CYP2D6 inhibition. Dextroamphetamine is also eliminated unchanged in urine, so the effect is likely small.
How serious is the interaction between Celecoxib and Dextroamphetamine?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is generally needed; monitor heart rate, blood pressure and stimulant adverse effects.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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