Drug interactions
Celecoxib + Dichlorphenamide
Severity: Moderate
Celecoxib and Dichlorphenamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Dichlorphenamide causes renal potassium loss and metabolic acidosis, while NSAIDs can impair renal function and may promote hyperkalemia, so the net potassium effect is unpredictable. A more relevant concern is that NSAIDs may reduce renal function and alter the handling of carbonic anhydrase inhibitors, and salicylate-type interactions are described for this class.
What this interaction means in plain words
Celecoxib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Dichlorphenamide belongs to Miscellaneous.
Why it happens
Opposing and unpredictable effects on potassium and renal function; no single well-established mechanism.
What to do
Monitor serum potassium, bicarbonate and renal function when starting or changing either drug. Adjust potassium supplementation according to results.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Dichlorphenamide
Frequently asked questions
Can I take Celecoxib with Dichlorphenamide?
MediHelp rates the interaction as moderate. Celecoxib and Dichlorphenamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Dichlorphenamide causes renal potassium loss and metabolic acidosis, while NSAIDs can impair renal function and may promote hyperkalemia, so the net potassium effect is unpredictable. A more relevant concern is that NSAIDs may reduce renal function and alter the handling of carbonic anhydrase inhibitors, and salicylate-type interactions are described for this class.
How serious is the interaction between Celecoxib and Dichlorphenamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor serum potassium, bicarbonate and renal function when starting or changing either drug. Adjust potassium supplementation according to results.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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