Drug interactions
Celecoxib + Disulfiram
Severity: Minor
Celecoxib and Disulfiram: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Disulfiram inhibits several CYP enzymes including CYP2C9, and may raise celecoxib concentrations. This could increase NSAID-related adverse effects, though clinical data are sparse.
What this interaction means in plain words
Celecoxib and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Disulfiram inhibits CYP2C9-mediated celecoxib metabolism.
What to do
Monitor for gastrointestinal, renal and blood pressure effects. Use the lowest effective celecoxib dose.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Disulfiram?
MediHelp rates the interaction as minor. Celecoxib and Disulfiram have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Disulfiram inhibits several CYP enzymes including CYP2C9, and may raise celecoxib concentrations. This could increase NSAID-related adverse effects, though clinical data are sparse.
How serious is the interaction between Celecoxib and Disulfiram?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for gastrointestinal, renal and blood pressure effects. Use the lowest effective celecoxib dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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