Drug interactions
Celecoxib + Donepezil
Severity: Minor
Celecoxib and Donepezil: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may marginally raise donepezil levels via CYP2D6 inhibition, which could increase cholinergic effects such as nausea or bradycardia. Additionally, both drugs can affect gastric mucosa, since cholinesterase inhibitors increase acid secretion while NSAIDs impair mucosal protection.
What this interaction means in plain words
Celecoxib and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Donepezil belongs to Central Nervous System.
Why it happens
Weak CYP2D6 inhibition by celecoxib reduces donepezil metabolism.
What to do
No dose change needed; monitor for GI symptoms, bradycardia and signs of GI bleeding.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Donepezil
- Donepezil + Dronedarone Contraindicated
- Donepezil + Pimozide Contraindicated
- Donepezil + Thioridazine Contraindicated
- Donepezil + Vandetanib Contraindicated
- Amiodarone + Donepezil Major
- Amisulpride + Donepezil Major
Frequently asked questions
Can I take Celecoxib with Donepezil?
MediHelp rates the interaction as minor. Celecoxib and Donepezil have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Celecoxib may marginally raise donepezil levels via CYP2D6 inhibition, which could increase cholinergic effects such as nausea or bradycardia. Additionally, both drugs can affect gastric mucosa, since cholinesterase inhibitors increase acid secretion while NSAIDs impair mucosal protection.
How serious is the interaction between Celecoxib and Donepezil?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change needed; monitor for GI symptoms, bradycardia and signs of GI bleeding.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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