Drug interactions
Celecoxib + Elvitegravir / cobicistat / emtricitabine / tenofovir df
Severity: Major
Celecoxib and Elvitegravir / cobicistat / emtricitabine / tenofovir df: major interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Tenofovir is renally eliminated and associated with nephrotoxicity, and NSAIDs can reduce renal perfusion, increasing the risk of acute kidney injury. Cobicistat also raises serum creatinine by inhibiting tubular secretion, which complicates monitoring. Celecoxib exposure could be affected by CYP2C9 modulation, though this is of uncertain significance.
What this interaction means in plain words
Celecoxib and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive nephrotoxic risk from NSAID prostaglandin inhibition and tenofovir tubular toxicity, with competition for renal elimination.
What to do
Avoid chronic or high-dose NSAID use with tenofovir-containing regimens and use paracetamol where possible. If needed, monitor serum creatinine, phosphate and urinary protein regularly.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates the interaction as major. Celecoxib and Elvitegravir / cobicistat / emtricitabine / tenofovir df can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Tenofovir is renally eliminated and associated with nephrotoxicity, and NSAIDs can reduce renal perfusion, increasing the risk of acute kidney injury. Cobicistat also raises serum creatinine by inhibiting tubular secretion, which complicates monitoring. Celecoxib exposure could be affected by CYP2C9 modulation, though this is of uncertain significance.
How serious is the interaction between Celecoxib and Elvitegravir / cobicistat / emtricitabine / tenofovir df?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid chronic or high-dose NSAID use with tenofovir-containing regimens and use paracetamol where possible. If needed, monitor serum creatinine, phosphate and urinary protein regularly.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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