Drug interactions
Celecoxib + Encainide
Severity: Minor
Celecoxib and Encainide: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Encainide depends on CYP2D6 for activation to active metabolites, and celecoxib weakly to moderately inhibits CYP2D6. Encainide is no longer marketed, so the combination is mostly of historical interest.
What this interaction means in plain words
Celecoxib and Encainide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Celecoxib inhibition of CYP2D6 may alter encainide metabolism.
What to do
Encainide is withdrawn. If ever used, monitor ECG for proarrhythmic effects.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Encainide?
MediHelp rates the interaction as minor. Celecoxib and Encainide have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Encainide depends on CYP2D6 for activation to active metabolites, and celecoxib weakly to moderately inhibits CYP2D6. Encainide is no longer marketed, so the combination is mostly of historical interest.
How serious is the interaction between Celecoxib and Encainide?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Encainide is withdrawn. If ever used, monitor ECG for proarrhythmic effects.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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