Drug interactions
Celecoxib + Escitalopram
Severity: Moderate
Celecoxib and Escitalopram: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
SSRIs deplete platelet serotonin and impair aggregation, and combined with an NSAID this increases the risk of upper gastrointestinal bleeding. Celecoxib has lower GI toxicity than non-selective NSAIDs but the combined risk is still raised.
What this interaction means in plain words
Celecoxib and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Escitalopram belongs to Central Nervous System.
Why it happens
Additive effects on platelet function and gastric mucosal injury.
What to do
Consider a proton pump inhibitor in patients with GI bleeding risk factors, and advise reporting melena or hematemesis. Use the lowest effective celecoxib dose.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Escitalopram
- Cisapride + Escitalopram Contraindicated
- Citalopram + Escitalopram Contraindicated
- Escitalopram + Isocarboxazid Contraindicated
- Escitalopram + Methylene blue Contraindicated
- Escitalopram + Phenelzine Contraindicated
- Escitalopram + Pimozide Contraindicated
Frequently asked questions
Can I take Celecoxib with Escitalopram?
MediHelp rates the interaction as moderate. Celecoxib and Escitalopram can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. SSRIs deplete platelet serotonin and impair aggregation, and combined with an NSAID this increases the risk of upper gastrointestinal bleeding. Celecoxib has lower GI toxicity than non-selective NSAIDs but the combined risk is still raised.
How serious is the interaction between Celecoxib and Escitalopram?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Consider a proton pump inhibitor in patients with GI bleeding risk factors, and advise reporting melena or hematemesis. Use the lowest effective celecoxib dose.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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