Drug interactions
Celecoxib + Feverfew
Severity: Moderate
Celecoxib and Feverfew: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Feverfew inhibits platelet aggregation in laboratory studies and may add to bleeding tendency with NSAIDs. Clinical reports are limited.
What this interaction means in plain words
Celecoxib and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive antiplatelet effects of feverfew (parthenolide) with NSAID-related mucosal injury.
What to do
Advise avoiding feverfew during celecoxib therapy, and stop it before surgery. Monitor for bruising and GI bleeding if combined.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Feverfew?
MediHelp rates the interaction as moderate. Celecoxib and Feverfew can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Feverfew inhibits platelet aggregation in laboratory studies and may add to bleeding tendency with NSAIDs. Clinical reports are limited.
How serious is the interaction between Celecoxib and Feverfew?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding feverfew during celecoxib therapy, and stop it before surgery. Monitor for bruising and GI bleeding if combined.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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