Drug interactions
Celecoxib + Glibenclamide
Severity: Moderate
Celecoxib and Glibenclamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib may modestly raise glyburide exposure through shared CYP2C9 metabolism, and NSAIDs may potentiate hypoglycemia. The effect is usually small, but older and renally impaired patients are at greater risk.
What this interaction means in plain words
Celecoxib and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Glibenclamide belongs to Endocrine.
Why it happens
Competition for CYP2C9 metabolism may raise glyburide concentrations.
What to do
Monitor blood glucose when starting or stopping celecoxib and lower the glyburide dose if hypoglycemia develops.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Glibenclamide
- Bosentan + Glibenclamide Contraindicated
- Cholic acid + Glibenclamide Major
- Ciprofloxacin + Glibenclamide Major
- Clarithromycin + Glibenclamide Major
- Fluconazole + Glibenclamide Major
- Glibenclamide + Insulin degludec-liraglutide Major
Frequently asked questions
Can I take Celecoxib with Glibenclamide?
MediHelp rates the interaction as moderate. Celecoxib and Glibenclamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib may modestly raise glyburide exposure through shared CYP2C9 metabolism, and NSAIDs may potentiate hypoglycemia. The effect is usually small, but older and renally impaired patients are at greater risk.
How serious is the interaction between Celecoxib and Glibenclamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood glucose when starting or stopping celecoxib and lower the glyburide dose if hypoglycemia develops.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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