Drug interactions
Celecoxib + Heparin
Severity: Moderate
Celecoxib and Heparin: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Concurrent use increases bleeding risk, especially gastrointestinal bleeding, because NSAIDs add antiplatelet and mucosal effects to heparin anticoagulation.
What this interaction means in plain words
Celecoxib and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Heparin belongs to Cardiovascular.
Why it happens
Additive hemostatic impairment: heparin enhances antithrombin activity while NSAIDs inhibit platelet function and damage GI mucosa.
What to do
Monitor for bleeding, hemoglobin and aPTT as appropriate. Prefer acetaminophen for analgesia when feasible.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Heparin
- Defibrotide + Heparin Contraindicated
- Heparin + Ketorolac Contraindicated
- Heparin + Oritavancin Contraindicated
- Acemetacin + Heparin Major
- Acetylsalicylic acid + Heparin Major
- Alteplase + Heparin Major
Frequently asked questions
Can I take Celecoxib with Heparin?
MediHelp rates the interaction as moderate. Celecoxib and Heparin can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Concurrent use increases bleeding risk, especially gastrointestinal bleeding, because NSAIDs add antiplatelet and mucosal effects to heparin anticoagulation.
How serious is the interaction between Celecoxib and Heparin?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for bleeding, hemoglobin and aPTT as appropriate. Prefer acetaminophen for analgesia when feasible.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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