Drug interactions
Celecoxib + Horse chestnut seed
Severity: Minor
Celecoxib and Horse chestnut seed: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Horse chestnut contains aesculin, a coumarin derivative, which may have anticoagulant activity. With celecoxib, bleeding risk may be modestly increased, though clinical data are lacking.
What this interaction means in plain words
Celecoxib and Horse chestnut seed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Theoretical additive hemostatic effects from coumarin-type constituents and NSAID mucosal injury.
What to do
Advise avoiding the herbal product in patients at bleeding risk and monitor for bruising or bleeding if used.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Horse chestnut seed?
MediHelp rates the interaction as minor. Celecoxib and Horse chestnut seed have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Horse chestnut contains aesculin, a coumarin derivative, which may have anticoagulant activity. With celecoxib, bleeding risk may be modestly increased, though clinical data are lacking.
How serious is the interaction between Celecoxib and Horse chestnut seed?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Advise avoiding the herbal product in patients at bleeding risk and monitor for bruising or bleeding if used.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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