Drug interactions
Celecoxib + Hydrocortisone
Severity: Moderate
Celecoxib and Hydrocortisone: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Corticosteroids combined with NSAIDs, including celecoxib, increase the risk of gastrointestinal ulceration and bleeding. Celecoxib carries a lower GI risk than non-selective NSAIDs but the risk is still raised. Fluid retention may also be additive.
What this interaction means in plain words
Celecoxib and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Hydrocortisone belongs to Endocrine.
Why it happens
Additive pharmacodynamic mucosal injury through impaired mucosal defense and healing.
What to do
Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in patients at GI risk; counsel on bleeding symptoms.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Hydrocortisone
- Hydrocortisone + Mifepristone Contraindicated
- Hydrocortisone + Poliovirus vaccine live oral trivalent Contraindicated
- Hydrocortisone + Smallpox vaccine live Contraindicated
- Adenovirus types 4 and 7 live + Hydrocortisone Major
- Aldesleukin + Hydrocortisone Major
- Aspirin + Hydrocortisone Major
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Hydrocortisone?
MediHelp rates the interaction as moderate. Celecoxib and Hydrocortisone can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Corticosteroids combined with NSAIDs, including celecoxib, increase the risk of gastrointestinal ulceration and bleeding. Celecoxib carries a lower GI risk than non-selective NSAIDs but the risk is still raised. Fluid retention may also be additive.
How serious is the interaction between Celecoxib and Hydrocortisone?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Use the lowest effective doses for the shortest time and consider a proton pump inhibitor in patients at GI risk; counsel on bleeding symptoms.
What other medicines interact with Hydrocortisone?
MediHelp also lists interactions of Hydrocortisone with, for example, Mifepristone, Poliovirus vaccine live oral trivalent, Smallpox vaccine live. The full list is on the Hydrocortisone page.
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