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Drug interactions

Celecoxib + Icosapent

Severity: Minor

Celecoxib and Icosapent: minor interaction.

Last updated

For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.

Summary

Icosapent ethyl may modestly prolong bleeding time, and celecoxib adds GI bleeding risk. Clinically significant bleeding is uncommon but possible in at-risk patients.

What this interaction means in plain words

Celecoxib and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.

Evidence level: Low

Why it happens

Additive effects on platelet function and mucosal integrity.

What to do

Periodically monitor for signs of bleeding, particularly if other antithrombotics are also used. No dose adjustment is usually needed.

What to ask your pharmacist

  • Is there anything I should notice while taking both?
  • Do I need to tell my doctor at the next visit?

Bring a full list of your medicines, including over-the-counter products, supplements and herbal remedies, to every pharmacy visit.

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Frequently asked questions

Can I take Celecoxib with Icosapent?

MediHelp rates the interaction as minor. Celecoxib and Icosapent have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Icosapent ethyl may modestly prolong bleeding time, and celecoxib adds GI bleeding risk. Clinically significant bleeding is uncommon but possible in at-risk patients.

How serious is the interaction between Celecoxib and Icosapent?

MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Periodically monitor for signs of bleeding, particularly if other antithrombotics are also used. No dose adjustment is usually needed.

What other medicines interact with Celecoxib?

MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.

Full monographs, dosing and an interaction checker in the MediHelp app

Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.

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