Drug interactions
Celecoxib + Indapamide
Severity: Moderate
Celecoxib and Indapamide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can attenuate the antihypertensive and diuretic effect of indapamide. Combined use in volume-depleted or older patients may also raise the risk of renal impairment.
What this interaction means in plain words
Celecoxib and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Celecoxib belongs to Musculoskeletal; Indapamide belongs to Cardiovascular.
Why it happens
Celecoxib inhibits renal prostaglandin synthesis, causing sodium and water retention and lowered renal perfusion.
What to do
Monitor blood pressure, renal function and electrolytes, and keep the patient well hydrated. Use the lowest effective celecoxib dose for the shortest time.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Indapamide
Frequently asked questions
Can I take Celecoxib with Indapamide?
MediHelp rates the interaction as moderate. Celecoxib and Indapamide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can attenuate the antihypertensive and diuretic effect of indapamide. Combined use in volume-depleted or older patients may also raise the risk of renal impairment.
How serious is the interaction between Celecoxib and Indapamide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, and keep the patient well hydrated. Use the lowest effective celecoxib dose for the shortest time.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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