Drug interactions
Celecoxib + Lofepramine
Severity: Moderate
Celecoxib and Lofepramine: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Celecoxib is a moderate CYP2D6 inhibitor and could raise exposure to lofepramine and its active metabolite desipramine, which are CYP2D6 substrates. This may increase anticholinergic effects, sedation or cardiac conduction effects, though clinical reports are limited.
What this interaction means in plain words
Celecoxib and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Celecoxib inhibits CYP2D6, reducing the metabolism of tricyclic antidepressants such as lofepramine and its metabolite desipramine.
What to do
Monitor for tricyclic adverse effects such as dry mouth, tachycardia and drowsiness, and consider a lower lofepramine dose if they appear. ECG monitoring is reasonable in patients with cardiac risk factors.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Lofepramine?
MediHelp rates the interaction as moderate. Celecoxib and Lofepramine can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Celecoxib is a moderate CYP2D6 inhibitor and could raise exposure to lofepramine and its active metabolite desipramine, which are CYP2D6 substrates. This may increase anticholinergic effects, sedation or cardiac conduction effects, though clinical reports are limited.
How serious is the interaction between Celecoxib and Lofepramine?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor for tricyclic adverse effects such as dry mouth, tachycardia and drowsiness, and consider a lower lofepramine dose if they appear. ECG monitoring is reasonable in patients with cardiac risk factors.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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