Drug interactions
Celecoxib + Lumacaftor / ivacaftor
Severity: Moderate
Celecoxib and Lumacaftor / ivacaftor: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Lumacaftor/ivacaftor has mixed effects on CYP2C9, with lumacaftor tending to induce it and ivacaftor tending to inhibit it, so celecoxib exposure may change unpredictably. This could cause reduced analgesic effect or increased NSAID adverse effects.
What this interaction means in plain words
Celecoxib and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Net modulation of CYP2C9, the main enzyme metabolizing celecoxib, through lumacaftor induction and ivacaftor inhibition.
What to do
Monitor clinical response and tolerability of celecoxib when starting or stopping lumacaftor/ivacaftor, and adjust the celecoxib dose as needed.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Lumacaftor / ivacaftor?
MediHelp rates the interaction as moderate. Celecoxib and Lumacaftor / ivacaftor can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Lumacaftor/ivacaftor has mixed effects on CYP2C9, with lumacaftor tending to induce it and ivacaftor tending to inhibit it, so celecoxib exposure may change unpredictably. This could cause reduced analgesic effect or increased NSAID adverse effects.
How serious is the interaction between Celecoxib and Lumacaftor / ivacaftor?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor clinical response and tolerability of celecoxib when starting or stopping lumacaftor/ivacaftor, and adjust the celecoxib dose as needed.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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