Drug interactions
Celecoxib + Meclofenamate
Severity: Major
Celecoxib and Meclofenamate: major interaction.
Last updated Sources: US FDA label
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal bleeding, renal impairment, fluid retention and hyperkalemia. Cardiovascular risk may also be additive.
What this interaction means in plain words
Celecoxib and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for.
Why it happens
Additive cyclooxygenase inhibition leading to greater mucosal injury, platelet dysfunction and reduced renal prostaglandin-dependent perfusion.
What to do
Avoid concurrent use of two NSAIDs and choose a single agent at the lowest effective dose. If a switch is made, stop the first drug before starting the other.
What to ask your pharmacist
- Does the benefit of taking both outweigh the risk in my case?
- Do I need any blood test, ECG or other check while on both?
- What early warning signs should I watch for, and what should I do if they appear?
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References
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Meclofenamate?
MediHelp rates the interaction as major. Celecoxib and Meclofenamate can interact in a way that may be serious. Using them together is sometimes necessary, but it needs a deliberate decision by the prescriber, a plan for monitoring, and clear advice on the warning signs to watch for. Combining two NSAIDs adds no proven benefit and increases the risk of gastrointestinal bleeding, renal impairment, fluid retention and hyperkalemia. Cardiovascular risk may also be additive.
How serious is the interaction between Celecoxib and Meclofenamate?
MediHelp rates it major, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Avoid concurrent use of two NSAIDs and choose a single agent at the lowest effective dose. If a switch is made, stop the first drug before starting the other.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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