Drug interactions
Celecoxib + Metaproterenol
Severity: Minor
Celecoxib and Metaproterenol: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metaproterenol can lower serum potassium through beta-2 stimulated cellular uptake, whereas NSAIDs can raise potassium slightly by reducing renal potassium excretion. The effects are opposing and clinically minor in most patients, so no significant interaction is expected.
What this interaction means in plain words
Celecoxib and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Opposing effects on serum potassium: beta-2 mediated intracellular shift versus NSAID-related reduced renal potassium excretion.
What to do
No specific action is needed beyond monitoring potassium in patients with renal disease or those using high doses of beta agonists.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Metaproterenol?
MediHelp rates the interaction as minor. Celecoxib and Metaproterenol have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metaproterenol can lower serum potassium through beta-2 stimulated cellular uptake, whereas NSAIDs can raise potassium slightly by reducing renal potassium excretion. The effects are opposing and clinically minor in most patients, so no significant interaction is expected.
How serious is the interaction between Celecoxib and Metaproterenol?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No specific action is needed beyond monitoring potassium in patients with renal disease or those using high doses of beta agonists.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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