Drug interactions
Celecoxib + Methyclothiazide
Severity: Moderate
Celecoxib and Methyclothiazide: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs can blunt the antihypertensive and diuretic effects of thiazides and, with diuretics, increase the risk of acute kidney injury in volume-depleted patients. The potassium effects partly offset each other.
What this interaction means in plain words
Celecoxib and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
NSAID inhibition of renal prostaglandins causes sodium and water retention and reduced renal perfusion, opposing thiazide action.
What to do
Monitor blood pressure, renal function and electrolytes, especially at the start of therapy or in elderly or dehydrated patients. Ensure adequate hydration.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Methyclothiazide?
MediHelp rates the interaction as moderate. Celecoxib and Methyclothiazide can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs can blunt the antihypertensive and diuretic effects of thiazides and, with diuretics, increase the risk of acute kidney injury in volume-depleted patients. The potassium effects partly offset each other.
How serious is the interaction between Celecoxib and Methyclothiazide?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor blood pressure, renal function and electrolytes, especially at the start of therapy or in elderly or dehydrated patients. Ensure adequate hydration.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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