Drug interactions
Celecoxib + Metronidazole
Severity: Minor
Celecoxib and Metronidazole: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Metronidazole has been reported to inhibit CYP2C9 substrates such as warfarin, so celecoxib levels might rise modestly. Clinical consequences are not well documented.
What this interaction means in plain words
Celecoxib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Celecoxib belongs to Musculoskeletal; Metronidazole belongs to Anti Parasitic.
Why it happens
Metronidazole may weakly inhibit CYP2C9-mediated metabolism of celecoxib.
What to do
No routine adjustment; monitor for NSAID adverse effects during prolonged co-therapy.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Other interactions of Metronidazole
- Ethanol + Metronidazole Contraindicated
- Metronidazole + Pimozide Contraindicated
- Amiodarone + Metronidazole Major
- Disulfiram + Metronidazole Major
- Ergotamine + Metronidazole Major
- Lomitapide + Metronidazole Major
Frequently asked questions
Can I take Celecoxib with Metronidazole?
MediHelp rates the interaction as minor. Celecoxib and Metronidazole have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Metronidazole has been reported to inhibit CYP2C9 substrates such as warfarin, so celecoxib levels might rise modestly. Clinical consequences are not well documented.
How serious is the interaction between Celecoxib and Metronidazole?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No routine adjustment; monitor for NSAID adverse effects during prolonged co-therapy.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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