Drug interactions
Celecoxib + Miconazole vaginal
Severity: Minor
Celecoxib and Miconazole vaginal: minor interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Miconazole is a CYP2C9 inhibitor, and vaginal use gives some systemic absorption. Celecoxib levels could rise, although the effect is likely small with short courses.
What this interaction means in plain words
Celecoxib and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised.
Why it happens
Miconazole inhibition of CYP2C9 reduces celecoxib metabolism.
What to do
No dose change is usually needed. Monitor for celecoxib adverse effects during longer courses.
What to ask your pharmacist
- Is there anything I should notice while taking both?
- Do I need to tell my doctor at the next visit?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Miconazole vaginal?
MediHelp rates the interaction as minor. Celecoxib and Miconazole vaginal have a small, usually unimportant interaction. Most people can take both; the pharmacist may still mention it so that any unexpected effect is recognised. Miconazole is a CYP2C9 inhibitor, and vaginal use gives some systemic absorption. Celecoxib levels could rise, although the effect is likely small with short courses.
How serious is the interaction between Celecoxib and Miconazole vaginal?
MediHelp rates it minor, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: No dose change is usually needed. Monitor for celecoxib adverse effects during longer courses.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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