Drug interactions
Celecoxib + Mipomersen
Severity: Moderate
Celecoxib and Mipomersen: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
Mipomersen commonly raises liver aminotransferases and can cause hepatic fat accumulation, and celecoxib has occasional hepatotoxicity. Using them together may compound liver injury risk.
What this interaction means in plain words
Celecoxib and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Additive potential for hepatocellular injury; no specific pharmacokinetic interaction is established.
What to do
Monitor ALT, AST and bilirubin at baseline and regularly during therapy, and interrupt treatment if significant elevations occur.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
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Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Mipomersen?
MediHelp rates the interaction as moderate. Celecoxib and Mipomersen can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. Mipomersen commonly raises liver aminotransferases and can cause hepatic fat accumulation, and celecoxib has occasional hepatotoxicity. Using them together may compound liver injury risk.
How serious is the interaction between Celecoxib and Mipomersen?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor ALT, AST and bilirubin at baseline and regularly during therapy, and interrupt treatment if significant elevations occur.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
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