Drug interactions
Celecoxib + Mycophenolate
Severity: Moderate
Celecoxib and Mycophenolate: moderate interaction.
Last updated
For healthcare professionals — reference only. This page is a brief summary, not medical advice and not a substitute for official labeling or clinical judgement. Always verify before prescribing or dispensing.
Summary
NSAIDs may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising levels of both. NSAIDs also add gastrointestinal toxicity and nephrotoxic risk in transplant patients.
What this interaction means in plain words
Celecoxib and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken.
Why it happens
Competition for renal tubular secretion of mycophenolic acid glucuronide and NSAID-related renal and gastrointestinal effects.
What to do
Monitor renal function and for gastrointestinal bleeding and myelosuppression. Use the lowest celecoxib dose for the shortest period.
What to ask your pharmacist
- Should I take them at different times of day?
- Does the dose of either medicine need to change?
- Is there anything I should avoid, such as alcohol or certain foods, while on both?
Pro+ members
Unlock the full page
Create an account and start a Pro+ trial to unlock the full management advice for Celecoxib and Mycophenolate, the additional notes, the evidence detail and the whole-prescription interaction checker.
- Full clinical management advice
- Additional notes
- Evidence detail
- Interaction checker for a whole prescription
Try Pro+ free for 7 days on the web. No card needed.
Other interactions of Celecoxib
- Celecoxib + Ketorolac Contraindicated
- Celecoxib + Ketorolac intranasal Contraindicated
- Aceclofenac + Celecoxib Major
- Acemetacin + Celecoxib Major
- Amiloride + Celecoxib Major
- Apixaban + Celecoxib Major
Frequently asked questions
Can I take Celecoxib with Mycophenolate?
MediHelp rates the interaction as moderate. Celecoxib and Mycophenolate can affect each other. The combination is often manageable, but it may need a change of dose, a change of timing, or extra checks while both are taken. NSAIDs may compete with mycophenolic acid glucuronide for renal tubular secretion, potentially raising levels of both. NSAIDs also add gastrointestinal toxicity and nephrotoxic risk in transplant patients.
How serious is the interaction between Celecoxib and Mycophenolate?
MediHelp rates it moderate, on a four-level scale (minor, moderate, major, contraindicated) based on published labels and references. What to do, in brief: Monitor renal function and for gastrointestinal bleeding and myelosuppression. Use the lowest celecoxib dose for the shortest period.
What other medicines interact with Celecoxib?
MediHelp also lists interactions of Celecoxib with, for example, Ketorolac, Ketorolac intranasal, Aceclofenac. The full list is on the Celecoxib page.
Full monographs, dosing and an interaction checker in the MediHelp app
Open the complete reference, check multi-drug interactions and use dosing tools in the MediHelp app.
